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Feb 25, 2007

骨髄多能性幹細胞は捏造だったのか

どうしても触れておきたい記事。またかよ,という感じですが,また捏造疑惑です。

万能細胞の論文に「重大不備」 02年ネイチャー誌掲載(朝日新聞2/25)

 ネズミの骨髄の幹細胞から、多くの臓器になりえる「万能細胞」を作り出した、とする02年6月の米ミネソタ大の研究者の論文について、「重大な不備」があるとの結論を同大がまとめた。AP通信が23日、報じた。

論文は、キャサリン・バーファイリー博士らが執筆し、英科学誌ネイチャーに掲載された。ネズミから取り出した幹細胞が、脳、心臓、肺、肝臓などの細胞に育つ能力があることが確認できたとしていた。

 しかし、同大の専門家委員会は、育った細胞を確認する過程に問題があり、そのデータに基づく論文の解釈は正しくない可能性があるとした。ただし、捏造(ねつぞう)ではなくミスだとしている。

より詳しい顛末のソースも,英語ですが,載せておきます。
Adult Stem Cell Study Flawed
Flawed stem cell data withdrawn

 MAPC(多能性成人前駆細胞)の存在は,発表以来相当騒がれましたが,その存在の確からしさについては議論となっていました。私も,このMAPCの検出を彼らの詳しいプロトコールも参照しながらこころみたことがありますが(骨髄ではなく臍帯血ですが),何度も試してもそれらしき多能性の細胞は出ませんでした。彼らは,疑い深い研究者を呼んで,MAPC培養トレーニングなども主宰していたようですが,血清ロットの問題だとか,作業者のテクニック上の問題だ,出現する確率がおそろしく低い,などといっているうちに,いつの間にか「MAPC」は難しい,という大方のコンセンサスが出来上がりました。彼らの提唱する「MAPC」という名称が,彼らのグループ以外に浸透しなかったのはやはり,彼らと同じ方法によって誘導できたグループがほとんどなかったからです。医療やビジネスとしても手を挙げるところがなかったのも同様で,百発百中でなかったためです。

 この論文が写真の取り違えのようないわゆる「ミス」でなく,捏造だったとしたら(そういえば,韓国のESグループの捏造のときも,最初は写真の取り違えのレベルの話でした),各国の研究者は大きな回り道をさせられたことになります。たとえば,MAPCの解析をしている研究者も国内にもいますが,一体彼らの調べていたものの正体はほんとうは何だったのかということになります。それ以外にも,MSC(間葉系幹細胞)やEPC(血管内皮前駆細胞)といった他の組織幹細胞との関係だとか,この論文を足がかりに書かれた論文の論理構築などにも影響が少なくないと思います。

 この問題は共同通信や朝日新聞がとりあげたことで国内でもますます注目される可能性があります。再生医療は眉唾ばかりだという印象になってしまっては,医療応用の面でも大きなマイナスになります。まずはどこまでが真実なのか,見極める必要がありますし,著者らは周囲の疑問に答える必要があるでしょう。

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海馬は記憶と関連する脳の中で非常に注目されている器官です。海馬は記憶と言うか、脳の情報の整理を行っているようです。記憶と記憶の結び付きを海馬が行うんですね。この海馬の神経細胞は年をとっても増えるんだそうです。子供のころから、脳は20歳過ぎてから減る一方と教えられてきましたよね。そういう話を聞くと人生20歳までだなんて、暗黙の誤解が生まれていたように思います。海馬は20歳過ぎてからも増え�... [Read More]

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